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IntraCytoplasmic Sperm Injection (ICSI)

IntraCytoplasmic Sperm Injection is a specialised and advanced technique of In Vitro Fertilization (IVF) used largely to treat severe male-factor infertility problems.

To fertilise an egg, the sperm’s head must attach to the egg’s outer layer and push the outer layer inside the egg, where fertilisation takes place.

Sometimes owing to different reasons, the sperm cannot reach the outer layer because the egg’s outer layer is thick or hard to penetrate. It is possible to help fertilise the egg with intracytoplasmic sperm injection (ICSI) and IVF in order to treat all of these issues.

There’s a single sperm implanted into a fully-developed egg in this procedure.

Hyaluronan (HA) in a medium binds sperm with normal DNA, allowing the selection of better-quality, more mature sperm for injection in ICSI.


There are two techniques by which an egg can be fertilised, either via IVF or ICSI. In IVF, a minimum of 50,000 swimming sperm is inserted near the egg. When a sperm enters an egg, fertilisation takes place.

Micropipettes are used during ICSI in order to inject just one little particle (sperm) into the egg’s core. In vitro growth of the fertilised egg lasts one to five days before the egg is implanted into the uterus or womb of a woman.


According to a study, ICSI fertilised 50 percent to 80 percent of eggs. But there are various difficulties that may occur during or after the ICSI procedure: all eggs are not fertilised with ICSI-IVF; fertilisation isn’t guaranteed even when a sperm is inserted into the egg.

The good news is that if fertilisation happens, the likelihood of having a single kid, twins, or triplets remains the same whether they have IVF with or without ICSI.


Though the success rate is great, if a woman gets pregnant via ICSI, there is a slight roughly 1.5 percent to 3 percent chance that the baby will have a serious congenital impairment.

Infertility, not the treatments required to overcome infertility caused by Beckwith-Weidman syndrome, Angelman syndrome, hypospadias, or sex chromosomal abnormalities, may be the cause of the slightly greater risk of congenital impairments. These anomalies are extremely rare, occurring in less than 1% of children conceived using this method.

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