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Preimplantation genetic diagnosis (PGD)

Embryos are screened for abnormal chromosomes before they are implanted in the uterus in Preimplantation Preimplantation genetic testing (PGD) is the term used to describe this process, which is carried out in a laboratory using IVF

The genetically healthy embryos are placed into the uterus after one or more cells from each embryo are obtained for genetic testing.

When one or both biological parents have a known genetic disorder, this is referred to as a preimplantation genetic diagnostic. Tests are done on the embryo in order to find out if it has any genetic abnormalities. For implantation, the uterus receives only healthy embryos. In the current post-conception diagnostic processes, if the results are undesirable, a pregnancy termination decision is often made. Preimplantation genetic testing provides an alternative. To avoid having a child with a genetic disorder before conception, PGD is the sole option.

Genetic testing

Embryonic cells are used, and a gene linked to a specific disease is tested. The results will demonstrate whether or not an embryo is healthy and free of disease or whether it is diseased and infected. Additionally, this testing will reveal that the embryo is carrying a specific condition, but it is unaffected by it or a carrier of the problem.

It is also possible to do amniocentesis or chorionic villus sampling in order to obtain an accurate karyotype during pregnancy. In this test, the fetus’ chromosomal count is compared to the typical 46. Down syndrome, for example, can be caused by chromosome abnormalities (Trisomy 21).

What is the process of genetic testing?

To conduct a genetic test, a sample of an embryo’s cells is obtained and sent for evaluation. During that period, the embryo is being developed in the IVF laboratory. FISH and SNP techniques can be used to accomplish PGD in a variety of ways, including in situ hybridization and fluorescent in situ amplification.

More and better methods are being developed all the time to make data more readily available and accurate. Genome sequencing and microarray testing are two of the most recent and used methods of genetic testing.

Who should be given PGD?

For those who have or are carriers of a known genetic disease, PGD is suggested. An older woman, a woman who has had many failed reproductive procedures, or someone whose ovaries aren’t working may benefit from it because of her history of miscarriage.

If you are interested in Preimplantation genetic diagnosis (PGD), contact us for the best fertility doctor in Karachi.

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